The objective of the study was to determine the relationship between work stress and attitudes during the COVID-19 pandemic of nursing personnel at the level of the Cono Norte - Tacna health micro-network, 2021. Methodology: the study corresponds to the type of research quantitative approach, relational level, nonexperimental design and cross-sectional. The study population was made up of 103 nursing professionals from the Cono Norte health micro-network. To collect the information, the technique of finding was used, making use of two instruments: Attitude Scale and Work Stress Test. Results: regarding stress levels, 57.3% of nursing professionals present a low level of stress, 38.8% a medium level, and only 3.9% present a high level of stress. Regarding the attitude of nursing professionals, 84.5% show an unfavorable attitude and 15.5% show favorable attitudes during the COVID-19 pandemic. Conclusions: there is a significant relationship between work stress and the attitudes of the nursing professional of the Cono Norte - Tacna health micro-network.