The objective of this research was to determine if there is a significant relationship between marital satisfaction and burnout syndrome in teachers of private Educational Units of the City of La Paz and Cochabamba, Bolivia, 2020. The sample consisted of 115 teachers who belonged to the Private Educational Institutions of the city of La Paz and Cochabamba, Bolivia and whose ages range from 25 to 60 years of both sexes. The instruments used to measure the variables were the Marital Satisfaction Scale (ESM): Pick and Andrade (1988) and the Maslach Burnout Inventory (MBI) Questionnaire: Maslach and Jackson in (1986). Finally, it was obtained as a result that there is a significant relationship between marital satisfaction and the degree of personal fulfillment. However, if there is a highly significant, moderate and negative relationship between marital satisfaction and the degree of emotional exhaustion; as well as, there is a significant slight and negative realization between marital satisfaction and the degree of depersonalization.