Christ commissioned his church to preach the gospel to the entire world and endowed it with spiritual gifts and ministries; this strategy began strongly over time. The objective of this study was to determine the effectiveness of the “Power” program in changing knowledge, attitudes and practices about spiritual gifts and ministries for the fulfillment of the mission in an Adventist church in the city of Arequipa. The design was quasi-experimental, pre-test, program implementation and post-test were taken. The PLS SEM model was used for statistical analysis. The results indicated that the level of knowledge, attitudes and practices increased significantly in the experimental group while there were no changes in the control group. There is sufficient statistical evidence where the value p< 0.05 allows us to conclude that the program was effective. It was found that a higher level of knowledge is related to a higher level of attitudes (0.4754) and practices (0.3882), both highly significant (p<0.001). Likewise, better attitudes are related to a higher level of practices (0.263), highly significant (p<0.001). In conclusion, the program was effective in changing the participants' knowledge, attitudes and practices about spiritual gifts and ministries because significant differences were found (p<0.05).